I find positioning of italics very difficult. Everything is skewed but axis are not so positioning a node at x:150, y:500 requires math with sinus functions or heavy use of guides which is quite annoying.
The real nightmare starts when I try to make ligatures. I am confused. How to make it with automatic alignment enabled?
Why 0,0 point (origin) is not at the bottom-left corner of metrics window but somewhere on the right?
What to do about it? How should a workflow look like?
The origin point is assumed at half the x-height, i.e., where the slanted LSB crosses it.
The measurements you see when you hold down ctrl+opt+cmd are in the italic angle, so it is easy to see if a point is exactly above another. Another way is to draw upright, then slant it and make corrections.
Can you describe what exactly you are trying to do with ligatures?