You disk is almost full

I’m working with a really large file and I get this message a lot You disk is almost full.

Checking Activity Monitor, the 3 main culprits are:
• coresymbolicationd
• kernal_task
• mds_stores

It get into the tens of GBs. The worst is coresymbolicationd it just continued to take up memory to the point where I have to restart my machine a few times to somehow get it to clear its cache. Can I avoid this? Is there a safe way to clear/delete the cache?

In the time it took to write this it grew over 100GB:

Gotta go restart

I found this: macos - what is in caches? - Ask Different

Can you check the Console app > Crashes if something is crashing a lot?